Genomic and Precision Medicine (Third Edition)
Chapter 8 - Aspiring to precision medicine for infectious diseases in resource limited settings
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Multiplexed host immune response biosensor for rapid sepsis stratification and endotyping at point-of-care
2022, Biosensors and Bioelectronics: XCitation Excerpt :The University of Texas authorized this study at Dallas Institutional Review Board (IRB#19MRO151). Matched patient plasma samples collected 6 h (T1) after enrollment (n = 44) and 24 h (T2) after enrollment (n = 50) were provided, stripped of identifying information, by ACESO (Rozo et al., 2020; Schully and Clark, 2019). Of the total 50 patient samples, 6 patient plasma samples were not collected at 6 h, with 44 matched samples.
Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping
2021, Biosensors and BioelectronicsCitation Excerpt :The limit of detection (LoD) described as the lowest measured concentration was calculated as 3 times SD of blank plasma. Plasma samples were collected under written informed consent as part of an ongoing observational trial of sepsis in resource-limited settings conducted by ACESO(Schully et al., 2017; Schully and Clark, 2019). Briefly, patients presenting to the emergency department of a participating hospital with at least two SIRS features and a suspected infection (SEPSIS-2 criteria) were eligible for enrollment.